アブストラクト（23巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Normalizing Effects of Peony Root Extract on Intracellular Calcium Increase by Pentylenetetrazol in Xenopus Oocytes Injected with a Seizure-related Gene, PTZ-17
Subtitle　： SHORT COMMUNICATION
Authors　： Noriyuki Yuyama1, Kagemasa Kajiwara1,2, Tokutaro Ishida1, Toyoji Aki1, Tadashi Tsuda3, Hiromi Ooguchi3, Aiko Sugaya3, Eiichi Sugaya1,2
Authors（kana）　：
Organization　： 1Department of Physiology, Kanagawa Dental College, 2Tsumura Institute for Oriental Medicine, School of Medicine, Keio University, 3Faculty of Pharmaceutical Sciences, Josai University
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 23
Number　： 1
Page　： 27-29
Year/Month　： 1995 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] Effects of peony root extract on the expression of the seizure-related gene, PTZ-17, were examined. An extract of peony root completely normalized the increase of intracellular calcium which had been induced by a convulsant drug, pentylenetetrazol, in Xenopus oocytes which had been injected with PTZ-17 RNA. This result together with the previous findings suggest that peony root extract is a main component for the anticonvulsant action of a herbal mixture, TJ-960, and it is hoped that it will create an antiepileptic therapy using control of the expression of seizure-related genes. This is completely different from actual therapy against epilepsy.
Practice　： Dentistry
Keywords　： Seizure, Anticonvulsant, Peony root extract, PTZ-17