アブストラクト（25巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Mechanisms of Cell-Cell Adhesion in Oral Mucosa and Oral Mucosal Lesions
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS : Adhesion Molecule
Authors　： Yoshinori Jinbu, Hiromi Naito, Tadahide Noguchi, Yoko Akasaka
Authors（kana）　：
Organization　： Department of Dentistry and Oral Surgery, Jichi Medical School
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 25
Number　： 2
Page　： 99-107
Year/Month　： 1997 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] The attachment of oral keratinocytes to the neighboring keratinocytes and to the underlying connective tissues is important to maintain the integrity of oral mucosa. These cell-cell and cell-matrix attachments are mediated through specific cell surface molecules called adhesion molecules, and disturbances of cell-cell and/or cell-matrix adhesion can cause certain oral mucosal lesions. We report here on the expression patterns of adhesion molecules in human normal oral mucosa and cultured oral keratinocytes originating from human gingiva, and discuss the molecular mechanisms of cell-cell adhesion between oral keratinocytes. Among oral mucosal lesions, some may be associated with the changes in the function and/or the expression of adhesion molecules. Oral lichen planus is a relatively common disease characterized by degeneration of the basal cells and the band-like infiltration of T-lymphocytes, and cell-cell interactions regulated by cytokines must be important in the pathogenesis. Pemphigus vulgaris is the most common bullous disease caused by antibody mediated intercellular adhesion defects. In oral cancer, reports have been published on profound alterations in intercellular and cell-matrix interactions, and there is no doubt that such alterations modulate cell behavior. We discuss the pathogenesis of these lesions from the point of view of cell-cell adhesion mechanisms.
Practice　： Dentistry
Keywords　： Adhesion molecules, Oral mucosa, Oral keratinocytes, Oral mucosal lesions