アブストラクト（28巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： The Relationship Between Type II procollagen-Cpeptide and Matrix Degrading Factors in Synovial Fluid of TMDs
Subtitle　： Selective Proceedings of 34th General Meeting of Kanagawa Odontological Society, 1999
Authors　： Yoshihiro Ijima, Masaru Kobayashi, Eiro Kubota
Authors（kana）　：
Organization　： Second Department of Oral and Maxillofacial Surgery, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 28
Number　： 1
Page　： 65-67
Year/Month　： 2000 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] The specific aims of this investigation were to detect type II procollagen C-peptide (pColl-H-C; chondrecalcin) from the synovial fluid (SF) of tempromandibular disorders (TMDs) and analyze its correlation with inflammatory cytokines (IL-1β, TNFα) or matrix degrading enzymes (MMPs). SF was obtained from 15 TMJs (7 osteoarthritis (OA), 8 internal derangement (ID)) in 15 patients and 8 normal asymptomatic TMJs of 8 volunteers (NR). Measurement of pColl-II-C, IL-1β and TNFα in the SF were performed by enzyme immunoassay (EIA). MMP activities were detected on gelatin enzymogram and type of MMPs was identified by Western blot analyses. The concentrations of pColl-II-C in SF were 1.O4, 0.39 and 2.59ng/ml in NR, ID and OA, respectively. The level of pColl-II-C in OA was significantly higher (p=0.029) than that of NR and ID. There was no significant correlation between the level of pColl-II-C and that of MMP2, MMP9, IL-1β or TNFα. These results suggest that TMJ OA is associated with increased synthesis of type II collagen accompanied with cartilage repair.
Practice　： Dentistry
Keywords　： Temporomandibular disorder (TMD), Type II procollagen-C-peptide, Matrix metalloproteinase (MMPs), Interleukin-1 beta (IL-1β), Tumor necrosis factor alpha (TNFα)