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アブストラクト（35巻2号：The Bulletin of Kanagawa Dental College）
English
| Title ： | Oxindolyl-L-alanine exhibits inhibitory activity against biofilm formation in Porphyromonas gingivalis |
|---|---|
| Subtitle ： | Selective Proceedings of 41st General Meeting of Kanagawa Odontological Society, 2006 |
| Authors ： | Nobushiro Hamada, Kiyoko Watanabe, Toshio Umemoto |
| Authors（kana） ： | |
| Organization ： | Department of Infection Control, kanagawa Dental College |
| Journal ： | The Bulletin of Kanagawa Dental College |
| Volume ： | 35 |
| Number ： | 2 |
| Page ： | 204-206 |
| Year/Month ： | 2007 / 9 |
| Article ： | Report |
| Publisher ： | Kanagawa Odontological Society |
| Abstract ： | [ABSTRACT]Porphyromonas gingivalis plays an important role in the initiation and progression of periodontal disease. In the present study, we tested whether the biochemical inhibition of tryptophanase, with the competitive inhibitor oxindolyl-L-alanine, could affect polystyrene colonization by Porphyromonas gingivalis. Oxindolyl-L-alanine inhibits, in a dose-dependent manner, indole production by strain ATCC 33277 grown in BHI-broth. Oxindolyl-L-alanine also inhibits the adherence of ATCC 33277 cells to polystyrene. At 0.5 mg/ml, oxindolyl-L-alanine exhibits inhibitory activity against biofilm formation in BHI-broth. These data suggest that indole, produced by the action of tryptophanase, is involved in polystyrene colonization by indole-producing bacteria, P. gingivalis. Indole may act as a signalling molecule to regulate the expression of adhesion and biofilm-promoting factors. |
| Practice ： | Dentistry |
| Keywords ： | Oxindolyl-L-alanine, Porphyromonas gingivalis, Biofilm, Indole |
