アブストラクト（37巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Human Submandibular Gland Produces Neuroendocrine Granules
Subtitle　： SHORT COMMUNICATION
Authors　： Juri Saruta, Keiichi Tsukinoki*, Naoto Shiiki*, Yusuke Kondo*, Sadao Sato
Authors（kana）　：
Organization　： Department of Craniofacial Growth and Development Dentistry, Division of Orthodontics, Kanagawa Dental College, *Department of Maxillofacial Diagnostic Science, Division of Pathology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 37
Number　： 1
Page　： 31-33
Year/Month　： 2009 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] The Grimelius silver method can be used to stain the secretory granules of various endo crine cells. The present study investigated neuroendocrine granules of the human submandibular gland (HSG) by the Grimelius silver method using paraffin sections. Argyrophilic Grimelius silver positive-cells were mainly observed among the serous cells of HSG. HSG may produce granules with neuroendocrine-like features. [Introduction] The salivary glands consist of the major salivary glands, including the parotid, submandibular, and sublingual glands, and numerous minor salivary glands scattered throughout the oral cavity. The main role of the salivary glands is to secrete saliva to assist in the digestion of food as well as to promote mastication and antimicrobial activities; however, other roles of the salivary glands may also exist, such as stress marker, tumor marker. It was recently found that chromogranin A (CgA) in saliva may be a reliable marker of stress conditions resulting from stimulation of sympathetic activity. CgA, an acidic glycoprotein, is fundamentally present in many endocrine cells such as the adrenal medulla, pancreas, and pituitary glands.
Practice　： Dentistry
Keywords　： Grimelius silver method, Argyrophilia, Human submandibular gland