アブストラクト（37巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Dysfunctional Mastication Affects Dopaminergic System in Rat Model of Alzheimer's Disease
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS: Stomatognathic System and Occlusion Medicine
Authors　： Katsuhiko Kimoto*1,*4, Sachio Kushida*1,*4, Norio Hori*1,*4, Toshiharu Yamamoto*2,*4, Minoru Onozuka*3,*4
Authors（kana）　：
Organization　： *1Division of Fixed Prosthodontics, Department of Oral and Maxillofacial Rehabilitation, Kanagawa Dental College, *2Department of Physiology and Neuroscience, Kanagawa Dental College, *3Department of Human Biology, Kanagawa Dental College, *4Research Center of Brain and Oral Science, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 37
Number　： 1
Page　： 49-53
Year/Month　： 2009 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] In order to establish a framework to understand the effects of dysfunctional mastication caused by soft-diet feeding on the dopaminergic neural system in both normal and Alzheimer's disease (AD) brain, we assessed dopamine (DA) release in the hippocampus using a micro-dialysis approach and learning ability and memory using step-through passive avoidance tests. In addition, we assessed the levels of tyrosine hydroxylase (TH), the ratelimiting enzyme, for the biosynthesis of dopamine in the ventral tegmental,area (VTA), using immunohistochemical methods. The results showed that when amyloid-E? protein infused rats were fed a soft diet, a decrease in DA release occurred in the hippocampus, and learning ability and memory were observed to diminish in comparison with rats that had been fed hard food. However, no change in the number of TH-immunopositive neurons was observed in the VTA of rats with dysfunctional mastication requiring a continuous soft diet. These observations suggest that soft-diet feeding may enhance a decline in hippocampal dopaminergic neuronal systems and result in impaired learning ability and memory in AD brain.
Practice　： Dentistry
Keywords　： Dopaminergic system, Soft-diet feeding, β-amyloid, Tyrosine hydroxylase