アブストラクト(7巻1号:The Bulletin of Kanagawa Dental College)

The Bulletin of Kanagawa Dental College

English

Title : Dental Anomalies and Defects Associated with Cleft Lip and Palate in Human Fetuses : A Histologic Observation
Subtitle : ORIGINAL ARTICLES
Authors : Hironori Kitamura
Authors(kana) :
Organization : Department of Oral Histology, Kanagawa Dental College
Journal : The Bulletin of Kanagawa Dental College
Volume : 7
Number : 1
Page : 1-30
Year/Month : 1979 / 3
Article : Original article
Publisher : Kanagawa Odontological Society
Abstract : [Abstract] In humans, epithelial regeneration begins to take place during the 13th week of gestation. In a great majority of fetuses younger than 12 weeks the tooth germs were severely afflicted and the entire oral epithelium was missing. In one of 10-week-old specimen the dental papilla of A|A was denuded due to missing of the dental organ with overlying tissues. In samples around the stage in which formation of dental hard tissue took place, tissue rarefaction or rodent cavities were frequently found in the E-D junction, i.e. not only the cells in the inner dental epithelium and odontoblastic layer but also those of the stratum intermedium. Duplicated lateral incisors were found in three cases with unilateral cleft lip. A pair of these duplicated lateral incisor buds had developed in a common dental sac, but no cleft lateral incisor bud indicating separation was found. Fused central incisors were found in a case with bilateral cleft lip. In fetuses of more than 19 weeks, not only amelogenesis imperfacta but also abnormal maturation of enamel and abnormal calcification of dentin were found. Not only were the location, type and degree of severity of the lesions inconsistent, but no significant correlation of the dental lesions to the type, size and location of the cleft was found. This suggests that the causation of malformations of teeth, lip and palate are probably environmental.
Practice : Dentistry
Keywords : Cleft palate, Dental anomalies, Human