アブストラクト（7巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Inducement of Antitumor Transplantation Activities : Treatment with Acrinol Combining Antigen (Ehrlich Ascites Carcinoma Cells)
Subtitle　： ORIGINAL ARTICLES
Authors　： Koichi Kato, Eriko Soma, Sakuji Fukushima, Saburo Kato
Authors（kana）　：
Organization　： Department of Bacteriology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 7
Number　： 1
Page　： 55-62
Year/Month　： 1979 / 3
Article　： Original article
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] A study was attempted on the antitransplantation (antitumor) activity which develops with the adjuvant activity of acrinol against Ehrlich solid and ascites carcinomas. When mice (ddY, C57 BL/6) were immunized with antigen in which Ehrlich ascites carcinoma cells were destroyed by an ultrasonic treatment and the cell debris was suspended in a 0.2% acrinol solution, a decrease of transplantibility was noted in the immunized mice, the transplanted carcinoma cells were hardly grown at the injected sites. Even if a tumor developed, its growth would involute in the process. Therefore, the survival rate would rise up. The antigen dose required to produce an antitransplantation effect was 1.0-0.01 mg nitrogen for one injection. The developed antitransplantation is able to resist a rechallenge and the effects last for more than 130 days.
Practice　： Dentistry
Keywords　： Tumor immunity, Antitumor, Acrinol, Adjuvant