アブストラクト（8巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Effects of Perhexiline, Propranolol and Dichloroisoproterenol on Intact, Reserpinized and Sympathectomized Canine Heart-Lung Preparations
Subtitle　： ORIGINAL ARTICLES
Authors　： Haruo Ito, Hiroshi Higashi, Youji Kawaguchi, Takahiko Shimura, Wataru Tokutomi
Authors（kana）　：
Organization　： Department of Pharmacology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 8
Number　： 1
Page　： 9-18
Year/Month　： 1980 / 3
Article　： Original article
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] The effects of perhexiline, propranolol and dichloroisoproterenol (DCI), on left ventricular function, myocardial oxygen consumption, left ventricular work, coronary flow, and myocardial efficiency were comparatively studied in the modified heart-lung preparations of intact, ganglionectomized and reserpinized dogs. Left ventricular function curves were not altered by all three agents in the three preparations. Coronary flow was increased while myocardial work-load was slightly decreased only by perhexiline. Myocardial efficiency was also increased only by perhexiline. These cardiac effects of perhexiline may be useful factors for its use in relief of angina pectoris.
Practice　： Dentistry
Keywords　： Perhexiline, Propranolol, DCI, Coronary sinus flow, Oxygen consumption, Cardiac work