アブストラクト（10巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Mediation of Ischemic Damage to Masseter Muscle and/or Skeletal Muscle by Hydrogen Ion and Free Radicals
Subtitle　： Review
Authors　： Eiichiro Okabe, Haruo Ito
Authors（kana）　：
Organization　： Department of Pharmacology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 10
Number　： 2
Page　： 135-140
Year/Month　： 1982 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] It is hypothesized that the intracellular mediators of ischemic injury of masseter muscle are hydrogen ions and the products of superoxide radicals. These two mediators are capable of initiating a circle of positive feedback that can explain the mechanical function of the ischemic skeletal muscle. Initially, with the increase in H+ ions, there is a reversible disruption of the excitation-contraction-coupling system. With progression of the ischemic process, superoxide radicals are produced that result in an irreversible disruption of phospholipid mediated transport systems. Further, the generation of these radicals is accelerated by the ongoing ischemic process and the decrease in intracellular pH. With the continued generation of both H+ ions and superoxide radicals, the ability of the skeletal muscular cell to maintain calcium homeostasis is destroyed and an irreversible state of rigor, due to intracellular calcium overload is observed. The hydrogen ion-free radical hypothesis is able to explain both the pathogenesis of the ischemic process and the protective mechanisms of pharmacologic interventions.
Practice　： Dentistry
Keywords　： Masseter Muscle, Calcium, ATPase, Free Radicals, Hydrogen Ion, Sarcoplasmic Reticulum