アブストラクト(11巻1/2号:The Bulletin of Kanagawa Dental College)

The Bulletin of Kanagawa Dental College

English

Title : Effects of Light and Heavy Orthodontic Force on Succinate Metabolism and Organic Matrix Synthesis in Rabbit Alveolar Bone
Subtitle : ORIGINAL ARTICLES
Authors : Sadao Sato, Masahisa Shiratori, Takao Kubota, Saburo Takahashi, Nagataka Sagara, Koichi Kuroki
Authors(kana) :
Organization : Department of Orthodontics, Kanagawa Dental College
Journal : The Bulletin of Kanagawa Dental College
Volume : 11
Number : 1/2
Page : 37-47
Year/Month : 1983 / 3
Article : Original article
Publisher : Kanagawa Odontological Society
Abstract : [Abstract] Japanese white rabbits were used to examine the effect of orthodontic forces upon the metabolic pathway and biosynthesis of organic matrix components in alveolar bone. Following orthodontic force application, the alveolar bones were removed and incubated with radioactive succinate for 120 minutes. After incubation, media and tissues were fractionated into intracellular, extracellular and organic matrix components. Each fraction was subjected to organic acid analysis, amino acid analysis and molecular sieve gel chromatography. The results indicated that newly synthesized organic acids and amino acids were released rapidly to extracellular space, especially in light orthodontic force application animals. It was suggested that newly synthesized organic acids, fumarate and malate, may have a important role in bone resorption with response to tooth movement. Furthermore, in experimental animals newly synthesized amino acid, which might be related to the protein synthesis, were at a high level in comparison with control animals. The incorporation of radioactive succinate into extracellular macromolecules was increased by application of mechanical force, indicating that orthodontic stimulation activated protein synthesis in alveolar bone.
Practice : Dentistry
Keywords : Succinate Metabolism, Alveolar Bone, Orthodontic Force