アブストラクト（11巻1/2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Developmental Changes in Testosterone and Dihydrotestosterone in the Rat Submandibular Gland
Subtitle　： ORIGINAL ARTICLES
Authors　： Mayumi Tarui, Shinri Koshika, Kenichi Inoue, Akira Sekimoto, Yoshiyuki Nakayama, Masahiko Hosaka*
Authors（kana）　：
Organization　： Department of Biochemistry, Kanagawa Dental College, *Department of Urology, Yokohama City University School of Medicine
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 11
Number　： 1/2
Page　： 63-67
Year/Month　： 1983 / 3
Article　： Original article
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] Testosterone (T) and 5α-dihydrotestosterone (DHT) concentrations in the rat submandibular gland (SMG) were measured by specific radioimmunoassay. SMG was obtained from male and female Wistar rats 0 to 10 weeks of age. T and DHT values in male and female SMG were low in rats less than 3 weeks of age, showing below 4.5ng/g. At 4 weeks of age, T levels greatly increased, revealing 15.1+-6.3ng/g for males and 18.4+-6.6ng/g for females. Thereafter, T concentrations in male and female SMG decreased to 3-5ng/g in rats from 5 to 10 weeks of age. DHT concentrations in both male and female were shown to be approximately 1.5-3 times higher than T at this period. The weight of male and female SMG increased remarkably at 4 weeks of age. From these results, it was concluded that no sexual difference existed in androgen concentrations in rat SMG, and that DHT began to accumulate at around 4 to 5 weeks of age. Furthermore, it is speculated that androgen plays a role in the growth and development of rat SMG.
Practice　： Dentistry
Keywords　： Rat Submandibular Gland, Testosterone and 5α-Dihydrotestosterone, Developmental Changes