アブストラクト（17巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Salivary Gland and Kinins in Reactive Hyperemia in Oral Tissues
Subtitle　： CLINICAL AND RESEARCH TOPICS Salivary Gland/Saliva
Authors　： Kazuo Todoki, Eiichiro Okabe, Masami Sugihara, Tsukasa Sekishita, Yoshifumi Wakasugi, Haruo Ito
Authors（kana）　：
Organization　： Department of Pharmacology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 17
Number　： 2
Page　： 137-140
Year/Month　： 1989 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Introduction] It has recently been documented that humoral and locally formed substances (especially kinin-like substance, prostaglandins and histamine) play an important role in the local regulation of blood flow in oral tissues. Kinins are potent vasodilator peptides released from precursors known as kininogens by enzymes known as kininogenases. The main kinino-genases are glandular and plasma kallikreins. Glandular kallikreins are found in the tissue and secretions of exocrine glands such as the salivary glands, pancreas and sweat glands as well as in the kidney and urine, and have been implicated in the regulation of blood flow to the exocrine glands and kidney, in water and electrolyte balance, in blood pressure regulation, and in the pathogenesis of experimental and human hypertension. Rabito et al. demonstrated that immunoreactive glandular kallikrein is present in the plasma, indicating that glandular kallikreins from the exocrine gland and/or the kidney are secreted not only into the exocrine secretion and the urine but also into the vascular compartment.
Practice　： Dentistry
Keywords　： Salivary Gland, Kallikrein-Kinin System, Reactive Hyperemia, Microcirculation