アブストラクト（17巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： The Submandibular Gland and Reproductive Function
Subtitle　： CLINICAL AND RESEARCH TOPICS Salivary Gland/Saliva
Authors　： Shinri Koshika, Takayuki Nishimura, Teruo Yoneda, Yoshiyuki Nakayama
Authors（kana）　：
Organization　： Department of Biochemistry, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 17
Number　： 2
Page　： 145-150
Year/Month　： 1989 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： The fact that the rodent submandibular gland (SMG) is an androgen dependent organ has been generally documented by the following evidences of androgen kinetics : the existence of the testosterone metabolizing enzyme 5α-reductase, sex difference of 5α-reductase affinity to testosterone, and the existence of 5α-dihydrotestosterone (DHT) binding protein in the cytosol or nuclear fraction. There are many kinds of biologically active substances in the gland (Table 1.) and almost all of them are androgen dependent. The organ's androgen dependency is enhanced at 4 weeks old. This is supported by the increased concentration of testosterone and DHT and a higher concentration of DHT than testosterone in the gland of 4-week-old mice or rats. And SMG also shows a significant increase in the weight at this stage. SMG's androgen dependency is thus well established but its physiological significance in SMG and/or in other tissues had been unclear. In recent years, a new physiological meaning of the substance and another function of SMG has been taken into consideration owing to an advanced hormone research technique.
Practice　： Dentistry
Keywords　： Submandibular Gland, Epidermal Growth Factor, Testis, Uterus