アブストラクト（17巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Regeneration of the Submandibular Gland in Rats : Immunohistochemical Observation of S-Phase Cells by Anti-Bromodeoxyuridine Monoclonal Antibody
Subtitle　： CLINICAL AND RESEARCH TOPICS Salivary Gland/Saliva
Authors　： Satoru Ozono, Kazuyoshi Sato, Isao Kondo, Yumi Ito, Mei Minabe
Authors（kana）　：
Organization　： Department of Pathology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 17
Number　： 2
Page　： 155-158
Year/Month　： 1989 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： Ligation of the excretory ducts of the submandibular glands in rats produces a marked glandular atrophy with structural changes. These changes look like symptoms of obstructive adenitis caused by calculi. The submandibular glands that became atrophied due to the duct ligation could be restored to normalcy after recanalization of the ducts. However, whether the recovery of acini is a result of cell differentiation in proliferating duct epithelia or the growth of the remnant acinar cells is yet to be clarified. Bromodeoxyuridine (BrdU) is regarded as an analog of thymidine, which is incorporated into DNA during the S-phase of the cell cycle. By an immunohistochemical method using anti-BrdU monoclonal antibody, it has become possible to identify the BrdU-containing nuclei. The present study was conducted to shed light on the regeneration process of acini in the duct-ligated/unligated gland of the submandibular glands in rats using a BrdU-labeling method. Experimental Obstruction of the Excretory Duct of the Submandibular Glands in Rats
Practice　： Dentistry
Keywords　： Submandibular Gland, Duct Ligation, Regeneration