アブストラクト（17巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Histology of the Submandibular Gland in Experimentally Induced Zinc-Deficient Mice
Subtitle　： CLINICAL AND RESEARCH TOPICS Salivary Gland/Saliva
Authors　： Isao Kondo, Satoru Ozono, Kazayoshi Sato, Yumi Ito
Authors（kana）　：
Organization　： Department of Pathology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 17
Number　： 2
Page　： 159-163
Year/Month　： 1989 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： Lowered serum zinc concentration levels in humans often cause hypogeusia, hyposomia, anorexia and other symptoms. It is reported that experimentally induced zinc-deficient animals develop marked growth failure, loss of hair and testicular atrophy on top of hypogeusia and hyposalivation. We suggest that a decrease in taste sensitivity under a zinc-deficient condition results from the reduced production of a neurotransmitter known as monoamine in the gustatory cells in the taste buds. However, the present authors do not rule out the possibility that hyposalivation or a change in the quality of saliva is a factor leading to hypogeusia or a taste disorder. Furthermore, changes in the contents of saliva may affect the living body in various ways. Regarding the dysfunction of the salivary gland associated with a zinc deficiency, histological study reports have not yet been published. So the authors made a histological investigation into morphological changes in the submandibular gland of experimentally induced zinc-deficient mice.
Practice　： Dentistry
Keywords　： Zinc-Deficient mice, Submandibular Gland, Granule Convoluted Tubules (GCT), NGF (nerve growth factor), EGF (epidermal growth factor)