アブストラクト（17巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Salivary Gland-Associated Synthesis and Transport of Immunoglobulin A
Subtitle　： CLINICAL AND RESEARCH TOPICS Salivary Gland/Saliva
Authors　： Toshio Umemoto
Authors（kana）　：
Organization　： Department of Oral Microbiology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 17
Number　： 2
Page　： 171-175
Year/Month　： 1989 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： The mechanisms mediating protection of the mucous membrane in the oral cavity against infectious agents are complex and only partly understood. The oral mucosa is continuously bathed in saliva, and an immune system providing antibodies in saliva may play a part in protecting the oral mucosa from microbial infection. The concept of a discrete, local or mucosal immune system separate from the systemic or serum immune system was developed. The antibody in saliva demonstrating a dissociation or lack of correlation between the antibodies were found in the serum. The predominant antibody in saliva is immunoglobulin A (IgA). Although IgA accounts for less than 3 percent of the total protein in parotid saliva, its concentration is at least 100 times that of IgG. The ratio of IgA and IgG in parotid saliva is thus on the average more than 400 times higher than the same ratio in the normal serum. Thus, this suggests that the salivary gland transfers IgA by a unique and selective mechanism. This review will outline some of the characteristics of the immunoglobulin A secreted from the salivary gland.
Practice　： Dentistry
Keywords　： s-IgA, Slivary Gland, Transport, Homing