アブストラクト（18巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Molecular Mechanism of Mechanical Stress in Bone and Periodontium
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS : Bone as a Tooth Supporting Tissue
Authors　： Takao Kubota, Masato Yamauchi, Rintarou Ueda, Toshiyuki Yoneyama, Chisato Saito, Sadao Sato, Yoshii Suzuki
Authors（kana）　：
Organization　： Department of Orthodontics, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 18
Number　： 2
Page　： 127-133
Year/Month　： 1990 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Introduction] Skeletal unloading due to bed rest, immobilization and weightlessness has been shown to result in a loss of bone. Also in orthodontic treatment, the application of mechanical force causes tooth movement through extensive local remodeling of the alveolar bone. The mechanism responsible for this phenomenon, however, is largely unknown. Several hypotheses have been proposed. Piezoelectric effects were initially thought to stimulate bone growth because bending dry bone produced an electrical current. Other researchers proposed that mechanical forces, such as stretch and compression caused by bone deformation, could be responsible for the load-induced bone remodeling. It is also possible that compression of bone induces the fluid in lacunae to flow over the cell surface. In these aspects, many researchers designed a number of methods to apply forces to bone or cells derived from bone or periosteum, in order to investigate the biochemical results of mechanical stimuli. In this manuscript, we wish to describe some of the evidence that mechanical stress induces remodeling of bone and periodontal tissue.
Practice　： Dentistry
Keywords　： Mechanical Stress, Prostaglandin, Osteopontin, Transforming Growth Factor-β (TGF-β), Tooth Movement