アブストラクト（18巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Character of Osteoblastic-Fibroblast Derived from Human Periodontal Ligament In Vitro
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS : Bone as a Tooth Supporting Tissue
Authors　： Toshio Kawase, Sadao Sato*, Shinji Deguchi**, Yoshio Kato, Shigeru Saito
Authors（kana）　：
Organization　： Department of Oral Biochemistry, Kanagawa Dental College, *Department of Orthodontics, Kanagawa Dental College, **Department of Periodontology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 18
Number　： 2
Page　： 135-141
Year/Month　： 1990 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Introduction] The periodontal ligament is a noncalcified connective tissue that functions in tooth support and lies between two mineralized tissues - cementum and alveolar bone. And also, this tissue is involved in the remodeling processes associated with tissue regeneration and physical stresses such as occlusion and mastication. By the developmental aspects, the periodontal ligament is derived from the dental follicle proper which contains undifferentiated cells of the fibroblasts, osteoblasts and cementoblasts. Therefore, the fibroblast-like cells of periodontal ligament may have some phenotypes of osteoblasts which have the ALPase expression, 1,25(OH)2D3 and PTH responsiveness and the synthesis of bone proteins. In this review, we focused on the in vitro induction of ALPase by Ca2+ regulatory hormones on the human periodontal ligament fibroblast-like cells (HPLF). [Establishment of Periodontal Ligament Fibroblast-Like Cells In Vitro] To obtain the cells of human periodontal ligament, Kawase, T. et al., Somerman, M.J. et al., Piche, J.E., Richards, D. and Ratherford, R.B. developed the culture of primary cells migrated from the tissue fragments by the sandwiched method or dispersed method.
Practice　： Dentistry
Keywords　： HPLF, Osteoblastic-Fibroblast, ALPase, 1,25(OH)2D3