アブストラクト（18巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Regulation by Transforming Growth Facter-β (TGF-β) in Bone and Periodontium
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS : Bone as a Tooth Supporting Tissue
Authors　： Takao Kubota, Masato Yamauchi, Kenichi Sasaguri, Rintarou Ueda, Jun Onozaki, Sadao Sato, Yoshii Suzuki
Authors（kana）　：
Organization　： Department of Orthodontics, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 18
Number　： 2
Page　： 143-149
Year/Month　： 1990 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Introduction] Bone is a rich source of growth factors, which can synthesize and retain a wide variety of molecules. Through the use of molecular hybridization, radioreceptor and radioimmunoassays, bone has been shown to produce transforming growth factor-β (TFG-β), insulin-like growth factor-I (IGF-I), IGF-II and β2 microgloblin (β2m). Additional growth factors extractable from the bone matrix include acidic fibroblast growth factor (aFGF), basic FGF (bFGF), osteogenin, bone morphogenic proteins (BMP) and platelet derived growth factor (PDGF). These factors retained in the matrix of bone are apparently due to the high proportion of calcium phosphate present and its inherent ionic affinity for many of these proteins. Of importance is the fact that the bone cells respond metabolically to each of these growth factors when tested in vitro. Most likely, these autocrine and paracrine factors are essential to the continued physiological processes of bone resorption and formation that constitute bone remodeling. In this manuscript we wish to describe some of the evidence that TGF-β is an important local bone growth regulators. [Transforming Growth Factor-β (TGF-β)] TGF-β is a homodimer and polypeptide of 25 KDa.
Practice　： Dentistry
Keywords　： Transforming Growth Factor-β (TGF-β), Osteoblast, Osteoclast, Periodontium