アブストラクト（18巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Oxygen Free Radicals as a Mediator of Bone Resorption
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS : Bone as a Tooth Supporting Tissue
Authors　： Eiichiro Okabe, Shun-suke Takahashi, Kasumi Kuse, Masahiro Norisue, Haruo Ito
Authors（kana）　：
Organization　： Department of Pharmacology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 18
Number　： 2
Page　： 151-159
Year/Month　： 1990 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Summary and Conclusions] There are several stages in the process of osteoclastic bone resorption at which oxygen free radicals may have an important effect. They could be involved in the degradation of bone matrix under the ruffled border of the osteoclasts. Since oxygen free radicals play an important role in many degradative processes, it is attractive to postulate that extracellular tissue components (e.g., bone structural molecules such as collagen and hyaluronic acid) are susceptible to cell-mediated oxygen free radical damage. The generation of oxygen free radicals may be particularly important in the bone resorption that occurs in association with an inflammatory disease. Oxygen-derived species are produced by activated phagocytes including monocytes, macrophages and neutrophils as reviewed in this article, and since these cells accumulate adjacent to the bone surfaces in chronic inflammatory diseases, radical production by these cells could be responsible for stimulating the osteoclast for formation or activation to resorb bone, or even directly enhancing matrix degradation. Endotoxin LPS may also directly stimulate bone resorption due to its ability to generate ・OH or a closely related species of free radicals. Chronic inflammatory diseases such as periodontal disease are associated with collections of chronic inflammatory cells occurring adjacent to bone with subsequent bone destruction. If this turns out to be one of the mechanisms by which bone is destroyed in these circumstances, then drugs that inhibit radical production or scavenge oxygen ree radicals may be useful therapeutic agents for this type of local bone destruction. Since the 1950s the generation of oxygen free radicals has been implicated in the aging process. The generation of oxygen free radicals may be linked particularly to the changes observed in senescent bone cells, which occur in age-related diseases such as periodontal disease.
Practice　： Dentistry
Keywords　： Free Radical, Endotoxin, Periodontal Disease, Bone Resorption