アブストラクト（20巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Effect of Potassium Gluconate on Potassium Transport in Rat Muscle : Its Extension to Aldosterone Excretion
Subtitle　： ORIGINAL ARTICLES
Authors　： Kasumi Kuse
Authors（kana）　：
Organization　： Department of Pharmacology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 20
Number　： 2
Page　： 106-113
Year/Month　： 1992 / 9
Article　： Original article
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] The effect of potassium gluconate (K-GL) on K+ transport of the rat extensor digitorum longus muscle was investigated. The reduced content of K+ in the muscle induced by 18 hr of cold (4℃) incubation was restored to the normal level when potassium chloride (KCl), potassium aspartate (Asp-K) and K-GL were present in the sequential incubation for 2 hr at 30℃; there was a significant difference between K-GL and KC1. The effect of K-GL, but not KCI and Asp-K, was not external glucose-dependent. The effect of potassium salts examined was completely abolished by the addition of ouabain. The inulin space, an extracellular fluid volume, and passive Na+ efflux of the muscle preparations were not affected by the potassium salts. Aldosterone excretion increased during the infusion of the potassium salts in dogs; the increase was independent of the form of potassium salt infused. Aldosterone production of the rat adrenal cortex was unaffected by the potassium salts. These results suggest that K-GL provides a substrate of glycolytic process and enhances active K+ transport of the skeletal muscle; and it is also postulated that the modification of passive Na+ leak pathway, extracellular fluid volume, and aldosterone synthesis and release are not responsible for the observed effect of K-GL.
Practice　： Dentistry
Keywords　： K-GL, K+ Transport, Skeletal Muscle, Na+, Aldosterone