アブストラクト（20巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： BKDC CLINICAL AND RESEARCH TOPICS Aging : Effect of Lifespan Preface
Subtitle　：
Authors　： Shinri Koshika
Authors（kana）　：
Organization　： Department of Biochemistry, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 20
Number　： 2
Page　： 157-157
Year/Month　： 1992 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： Aging affects many aspects of the endocrine, nervous and circulatory systems, and further affects the various factors related to these organs. Physiological functions definitely decline with the advancing of age. However, aging and age-related physiological or pathological changes are not a disease, but a natural process which are ultimately shown by all individuals. Therefore, aging may be defined as "a characteristic pattern of late-life events." The invariable transformation of aging is thereby distinguished from disease and age-related disease. From this viewpoint, "aging" was subjected to a discussion as BKDC Clinical and Research Topics and reviewed by seven ad hoc authors. Okabe et al. discuss the relation of aging and superoxide anion radical scavenger, and the changes of superoxide dismutase activity in the senescent bone cells having a possible relevance to the periodontal disease; Sugaya, the mechanism of TJ-960, which has been used as an anticonvulsant, and the herbal medicine is very effective against epilepsy; Kato et al., aging is caused by the cell senescence-related gene, and loss or inactivation of this gene predisposes to tumorigensis; Koshika et al., age-related changes of blood hormones and in some instance their tropic hormones; Sakurai et al., the relationship between the gravitational changes and bone changes, and this change resembles the phenomena of senescence bone; Deguchi and Hori, physiological changes occurring in the periodontium and classification of the periodontal disease in relation to aging; and, Kawase et al., possible role of TGF-β in remodeling of the age advanced periodontium, from the results of a series of HPLF (human periodontal ligament fibroblast-like cell) culture.
Practice　： Dentistry
Keywords　：