アブストラクト（20巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Aging and Oxygen Free Radical System : Possible Role in Diseases in Oral Region
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS Aging : Effect of Lifespan
Authors　： Eiichiro Okabe, Takashi Kiyose, Katsufumi Nanba, Tetsuya Ishibashi, Fujiko Muroi, Haruo Ito
Authors（kana）　：
Organization　： Department of Pharmacology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 20
Number　： 2
Page　： 159-169
Year/Month　： 1992 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Introduction] Oxygen free radical reactions, ubiquitous in the living systems, are of both enzymatic and nonenzymatic origin. Enzymatic oxygen free radical reactions include those involved in the respiratory chain, prostaglandin synthesis, the cytochrome P-450 system and phagocytosis. The copper or iron catalyzed reactions of oxygen with organic compounds and those initiated by ionizing radiation are examples of nonenzymatic oxygen free radical reactions. The oxygen free radicals formed in the above reactions include hydroxyl radical ('OH), superoxide radical ('O2-), alkoxyl (LO'), peroxyl (LOO'), etc., as well as singlet oxygen (1O2). These reactive intermediates serve to bind the multiplicity of oxygen free radical reactions proceeding continuously throughout the cells and tissues into a network of reactions with variable degrees of interaction between them. The net change in chemical composition produced per unit time by the network serves as a measure of the number of oxygen free radical reactions present, the oxygen free radical reaction level, as well as of the number of oxygen free radicals.
Practice　： Dentistry
Keywords　： Oxygen Free Radicals, Aging, Lipid Peroxidation, Periodontal Disease, Antioxidants