アブストラクト（20巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Negative Regulation of Tumorigenesis : Tumor Suppressor Gene and Cell Senescence-Related Gene
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS Aging : Effect of Lifespan
Authors　： Yasumasa Kato, Shinri Koshika, Yoshiyuki Nakayama
Authors（kana）　：
Organization　： Department of Biochemistry, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 20
Number　： 2
Page　： 179-187
Year/Month　： 1992 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Introduction] Aging, as well as tumorigenesis, is one of the serious matters in our life, and should disclose the mechanisms of the subjects. Aging is not inseparable from the onset of tumorigenesis in many instances. We need to review their mechanisms of them severally. It is well known that the incidence rate of tumorigenesis increases in the elderly, and that the alteration of immune status is caused while aging. In recent studies new concepts about the explanation for the regulation of tumorigenesis has been accepted, since various genetical and biological technologies have been adapted on the tumor cell analysis, involving karyotypic examination, restriction fragment length polymorphism (RFLP) analysis, polymerase chain reaction (PCR), cellular diffusion, and microcell transfer. Consequently, it was found that the chromosome was specifically lost in the tumor cells. On the contrary, various tumor suppressor genes were identified from the lost region of the chromosome in the cells with tumorigenesis. In addition, it was reported that loss of the putative cell senescence-related gene may lead to the immortality in the in vitro studies.
Practice　： Dentistry
Keywords　： Tumorigenesis, Tumor-Suppressor Gene, Cell Senescence-Related Gene, Microcell Transfer, Heterozygosity