アブストラクト（21巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Allergic Reactions to Anti-Inflammatory Agents after Sialolithotomy
Subtitle　： CASE REPORT
Authors　： Kazu-ichi Yoshida, Akiyoshi Ohsawa, Akihira Yamaguchi, Akira Hino, Tohru Nagai, Yutaka Kobayashi, Masahiro Noguchi, Kenji Kawahara*, Yoshiro Honma*
Authors（kana）　：
Organization　： Department of Anesthesiology, Kanagawa Dental College, *Second Department of Oral and Maxillofacial Surgery, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 21
Number　： 2
Page　： 72-76
Year/Month　： 1993 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Introduction] Allergic reactions to drugs represent unpredictable and occasionally life threatening events. Fatal drug reactions have been estimated to occur in 0.1% of medical inpatients and in 0.01% of surgical inpatients. Allergic drug reactions involving immunological mechanisms account for approximately 5% to 10% of adverse drug reactions. In dentistry, especially in oral and maxillofacial surgery, antibiotics and nonsteroidal anti-inflammatory drugs are indispensable, but often cause allergic reactions. Allergic drug reactions, by definition, should be mediated by specific antibodies or sensitized lymphocytes. Coombs and Gell classified immunopathologic reactions into four types: immediate hypersensitivity, cytotoxic antibodies, immune complex (Arthus reaction) and cell-mediated hypersensitivity. Although some drug reactions have obscure immunologic pathogenesis and are not included in this classification, it helps to clarify the major mechanisms of allergic tissue injury. The Coombs and Gell type 1 reaction (anaphylactic reaction) involves contact between antigen and antibody of the Ig-E immunoglobulin on the surface of mast cells or blood basophil, which then release potent vasoactive mediators that include histamine, anaphylactic slow-reacting substances (leukotrienes C and D), eosinophil chemotactic factor, platelet activating factor, and others of unknown biologic importance.
Practice　： Dentistry
Keywords　： Drug Allergy, Aspirin, Diclofenac Sodium, Lymphocyte Stimulating Test, Anaphylactoid Reaction