アブストラクト（21巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： A Pain Producing Substance and Analgesic Substances in the Tooth Pulp
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS Pain
Authors　： Reizo Inoki, Teruo Kudo
Authors（kana）　：
Organization　： Department of Pharmacology, Osaka University Faculty of Dentistry
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 21
Number　： 2
Page　： 85-88
Year/Month　： 1993 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Introduction] Toothaches are in general classified in two categories: one is caused by a noxious stimulus itself to dentin, which is followed by an acute sharp pain, and another is induced by an inflammatory process in dental pulp, which shows a chronic dull pain. It has been thought that the former is due to direct stimulation of free nerve endings in the tooth pulp and the latter is due to indirect stimulation of them by pain-producing substances which appeared in the tissue during inflammation. On the other hand, it has been known that endogenous analgesic substances exist in the tooth pulp. In the present paper, we would like to review a relationship in the pain mechanism of the tooth pulp between a pain-producing substance, bradykinin (BK), and endogenous analgesic substances, enkephalins (EKs), both of which are induced in inflammatory dental pulp. [Production of Bradykinin in the Tooth Pulp] When the pulp tissues are stimulated by various stimulations such as electrical, chemical or mechanical stimulation, BK, an inflammatory chemical mediator, is produced in interstitial spaces of the tissue.
Practice　： Dentistry
Keywords　： Pain, Tooth Pulp, Bradykinin, Enkephalin