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アブストラクト（22巻2号：The Bulletin of Kanagawa Dental College）
English
| Title ： | Developmental Exchange of Estrogen and Estrogen Receptor in Rat Submandibular Gland |
|---|---|
| Subtitle ： | ORIGINAL ARTICLES |
| Authors ： | Hiroyuki Hayashi, Hirokazu Kato, Kumi Akimoto, Sozo Sasa |
| Authors（kana） ： | |
| Organization ： | Department of Oral Histology, Kanagawa Dental College |
| Journal ： | The Bulletin of Kanagawa Dental College |
| Volume ： | 22 |
| Number ： | 2 |
| Page ： | 53-60 |
| Year/Month ： | 1994 / 9 |
| Article ： | Original article |
| Publisher ： | Kanagawa Odontological Society |
| Abstract ： | [Abstract] The concentration of 17β-estradiol (E2) was measured by radioimmunoassay in the submandibular glands (SMG) and plasma of male and female Wistar rats ranging in age from 2 to 10 weeks. The SMG E2 concentration in animals aged 2 to 3 weeks was significantly higher than that of adult rats (10 weeks old). The plasma E2 levels of rats aged 2 to 3 weeks were also higher than those of 10-week-old rats. At 10 weeks, the concentration of E2 in female rat plasma changed according to the rat's estrus cycle. SMG E2 levels were consistently low and appeared to have no correlation with plasma E2 levels. After administration of 3H-E2 to prepuberty and mature male and female rats, the SMG of prepuberty rats and the uterus of mature rats retained radioactive hormones from the blood. The present study was undertaken to quantitatively determine if the SMG in adult and prepuberty rats contain the E2 receptor (ER). The amount of ER observed in prepuberty male and female rat SMG was much higher than that in mature rat SMG. Prepuberty rat E2 binding protein showed specificity to E2 and not to progesterone (P4) or dihydrotestosterone (DHT). SMG E2 binding protein was judged by immunodetection with an ER monoclonal antibody (H-222, Abotte), and only one component of 67 kDa was detected in prepuberty rat SMG. Prepuberty male and female rat SMG are influenced by E2, and this E2 dependency is related to age. |
| Practice ： | Dentistry |
| Keywords ： | Estrogen, Estrogen Receptor, Prepuberty Rat Submandibular Gland |
