アブストラクト（23巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Effect of Mechanical Stress on Protein Synthesis in Human Periodontal Ligament Cells
Subtitle　： ORIGINAL ARTICLES
Authors　： Katsuhiro Nishiyama, Naohito Nozaki, Mikio Miyama, Akira Kawata, Makoto Fujieda*, Toshio Kawase, Shigeru Saito
Authors（kana）　：
Organization　： Department of Oral Biochemistry, Kanagawa Dental College, *Department of Social Dentistry, Ohu Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 23
Number　： 1
Page　： 3-8
Year/Month　： 1995 / 3
Article　： Original article
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] The purpose of this study was to characterize the ability of cultured human periodontal ligament fibroblast (HPLF) to synthesize DNA, total protein and collagen when mechanical stretching and Epidermal Growth Factor (EGF) were applied. DNA synthesis of HPLF was increased 1.3 fold by stretching and 1.6 fold by stretching +EGF as compared to control cells. The protein content of cell layers of HPLF was significantly increased by stretching and more so by stretching +EGF. The rate of collagen synthesis did not significantly change in response to stretching or EGF, alone or in combination.
Practice　： Dentistry
Keywords　： Periodontal ligament, Mechanical stress, DNA, Collagen synthesis