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アブストラクト(23巻1号:The Bulletin of Kanagawa Dental College)
English
Title : | Normalizing Effects of a Herbal Mixture, TJ-960, on Intracellular Calcium Increase by Pentylenetetrazol in Xenopus Oocytes Injected with a Seizure-related Gene, PTZ-17 |
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Subtitle : | SHORT COMMUNICATION |
Authors : | Noriyuki Yuyama1, Kagemasa Kajiwara1,2, Toyoji Aki1, Tokutaro Ishida1, Shintaro Hattori1, Eiichi Sugaya1,2 |
Authors(kana) : | |
Organization : | 1Department of Physiology, Kanagawa Dental College, 2Tsumura Institute for Oriental Medicine, School of Medicine, Keio University |
Journal : | The Bulletin of Kanagawa Dental College |
Volume : | 23 |
Number : | 1 |
Page : | 25-26 |
Year/Month : | 1995 / 3 |
Article : | Report |
Publisher : | Kanagawa Odontological Society |
Abstract : | [Abstract] Effects of a herbal mixture, TJ-960, on the expression of the seizure-related gene, PTZ-17, were examined. TJ-960 completely normalized intracellular calcium increase induced by a convulsant drug, pentylenetetrazol, in Xenopus oocytes injected with PTZ-17 RNA. This result together with the previous findings suggest that TJ-960 is a promising future anticonvulsant drug which not only has an effect on the normalization of abnormal intracellular calcium increase but also presents the possibility of a gene therapy which is based on a completely different concept than the conventional therapy. |
Practice : | Dentistry |
Keywords : | Seizure, Anticonvulsant, Herbal medicine, PTZ-17 |