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アブストラクト(23巻1号:The Bulletin of Kanagawa Dental College)
English
Title : | Normalizing Effects of Peony Root Extract on Intracellular Calcium Increase by Pentylenetetrazol in Xenopus Oocytes Injected with a Seizure-related Gene, PTZ-17 |
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Subtitle : | SHORT COMMUNICATION |
Authors : | Noriyuki Yuyama1, Kagemasa Kajiwara1,2, Tokutaro Ishida1, Toyoji Aki1, Tadashi Tsuda3, Hiromi Ooguchi3, Aiko Sugaya3, Eiichi Sugaya1,2 |
Authors(kana) : | |
Organization : | 1Department of Physiology, Kanagawa Dental College, 2Tsumura Institute for Oriental Medicine, School of Medicine, Keio University, 3Faculty of Pharmaceutical Sciences, Josai University |
Journal : | The Bulletin of Kanagawa Dental College |
Volume : | 23 |
Number : | 1 |
Page : | 27-29 |
Year/Month : | 1995 / 3 |
Article : | Report |
Publisher : | Kanagawa Odontological Society |
Abstract : | [Abstract] Effects of peony root extract on the expression of the seizure-related gene, PTZ-17, were examined. An extract of peony root completely normalized the increase of intracellular calcium which had been induced by a convulsant drug, pentylenetetrazol, in Xenopus oocytes which had been injected with PTZ-17 RNA. This result together with the previous findings suggest that peony root extract is a main component for the anticonvulsant action of a herbal mixture, TJ-960, and it is hoped that it will create an antiepileptic therapy using control of the expression of seizure-related genes. This is completely different from actual therapy against epilepsy. |
Practice : | Dentistry |
Keywords : | Seizure, Anticonvulsant, Peony root extract, PTZ-17 |