アブストラクト（23巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Reactive Oxygen Species and Viral Infections
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS INFECTION
Authors　： Eiichiro Okabe, Kazuo Todoki, Tetsuya Ishibashi, Katsufumi Nanba, Masahiro Norisue, Shinobu Kuwaki
Authors（kana）　：
Organization　： Department of Pharmacology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 23
Number　： 2
Page　： 117-128
Year/Month　： 1995 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] Since the appearance of photosynthesis on our planet, all living organisms have been facing a new abundant, extremely reactive element, oxygen. This element is used for the synthesis of highly energetic compounds, but can also generate molecules capable of damaging the constituents of living structures, including proteins, nucleic acids and lipids. It is, therefore, no surprise that all biological organisms have evolved multiple and sophisticated ways to reduce the detrimental effects of oxygen. For cells and tissues of highly organized animals, particularly cells of the immune system, superoxidation products play an important role, via oxidative stress, inactivation, inflammation and viral and bacterial infections. Oxidative stress, a known activator of the human immunodeficiency virus (HIV) replication in vitro, has a potential role as a cofactor of HIV disease progression. Some arguments supporting the role of oxidative stress as a cofactor in HIV activation are summarized in this review. The role of intracellular antioxidants such as glutathione (GSH), and drugs and nutriceutical agents promoting GSH synthesis, are also discussed.
Practice　： Dentistry
Keywords　： Reactive oxygen species, Human immunodeficiency virus, NF-κB, Glutathione, Cytokines