アブストラクト（24巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Availability of Autologous Blood Transfusion with rHuEPO for Surgery on Oral Region
Subtitle　： ORIGINAL ARTICLES
Authors　： Yuuichi Sasakura, Minoru Kobori, Gouichi Matsumoto, Syuuji Matsuzawa, Kazuaki Shinozuka, Junichi Shindo
Authors（kana）　：
Organization　： First Dept. of Oral and Maxillofacial Surgery, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 24
Number　： 1
Page　： 3-8
Year/Month　： 1996 / 3
Article　： Original article
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] Even now, many risks are inherent in allogeneic blood transfusion (ALBT) : GVHD (graft versus host reaction disease), and transmission of infections such as the hepatitis virus and HIV. Hence, we selected autologous blood transfusion (ABT) for surgery on jaw deformities. Because it is elective surgery and generally the patients are young, problems with ALBT bring a big social loss. However, ABT has the drawback that preoperative autologous blood transfusions (ABC) cause anemia, which should be restored at the time of the operation. We utilized recombinant human erythropoietin (rHuEPO) to minimize for the problem of anemia. ABT used with rHuEPO in study group A (group A) is applied to ten jaw surgery cases. A total of 800ml of blood was collected as ABC from each individual ; ABT without using rHuEPO in study group B (group B) was also studied in three of the cases of jaw surgery ; a total of 400ml of blood was collected from each individual in group B. Over a period of two weeks before the operation, rHuEPO was administered for a total of 36,000IU per individual. Oral administration of ferrous sulfate was given in both groups. We investigated the changes of peripheral blood cells due to ABC including RBC, Hb, Ht and Plt counts. The patients did not complain about collecting the 800ml of blood, and the method of using rHuEPO did not negatively influence their quality of life. Further, despite a two fold quantity of ABC, patients given rHuEPO compared with patients of group B recovered well from anemia. Thus rHuEPO was also useful for pre-deposit ABT in surgery of the oral region.
Practice　： Dentistry
Keywords　： Recombinant human erythropoietin, Oral surgery, Autologous blood transfusion