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アブストラクト（24巻2号：The Bulletin of Kanagawa Dental College）
English
| Title ： | Local Administration of Recombinant Interleukin-2 and Interferon-β in Oral Squamous Cell Carcinoma |
|---|---|
| Subtitle ： | ORIGINAL ARTICLES |
| Authors ： | Gouichi Matsumoto, Yuuichi Sasakura, Shuuji Matsuzawa, Junichi Shindo |
| Authors（kana） ： | |
| Organization ： | First Department of Oral Surgery, Kanagawa Dental College |
| Journal ： | The Bulletin of Kanagawa Dental College |
| Volume ： | 24 |
| Number ： | 2 |
| Page ： | 57-63 |
| Year/Month ： | 1996 / 9 |
| Article ： | Original article |
| Publisher ： | Kanagawa Odontological Society |
| Abstract ： | [Abstract] Based on a preclinical study showing the synergistic anti-tumor effects of recombinant interleukin-2 (IL-2) and interferon-β (IFN-β) on mice tumors, we investigated the effects of the combination of these cytokines in patients with oral squamous cell carcinoma. The study showed immunological effects on the activity of T cells and natural killer (NK) cells. Three patients were treated with intra-and peri-tumoral injections of IL-2 and IFN-β for ten consecutive days. None of the patients achieved a complete or partial response. However, there was a gradual increase in the enhancement of the NK activity of the peripheral blood lymphocytes. The each percentage of Leu-11, Leu-7, Leu-3a and Leu-2a positive cells was slightly increased in peripheral blood lymphocytes. Furthermore, the Leu-2a, Leu-4, Leu-3a and Leu-11 positive cells infiltrated in cancer tissues after the administration of IL-2 and IFN-β. |
| Practice ： | Dentistry |
| Keywords ： | Local administration, Interleukin-2, Interferon-β, Oral squamous cell carcinoma |
