アブストラクト(24巻2号:The Bulletin of Kanagawa Dental College)

The Bulletin of Kanagawa Dental College

English

Title : BKDC CLINICAL AND RESEARCH TOPICS : Apoptosis Preface
Subtitle :
Authors : Eiichiro Okabe
Authors(kana) :
Organization :
Journal : The Bulletin of Kanagawa Dental College
Volume : 24
Number : 2
Page : 89-90
Year/Month : 1996 / 9
Article : Report
Publisher : Kanagawa Odontological Society
Abstract : When cells are exposed to life-threatening conditions, many genes are newly activated with products that serve to warn other cells and defend the organism. For instance, UV light, γ rays, an elevated temperature, oxygen radicals, pro-and eukaryotic parasites, viruses, and cytokines (which are released by pathogen-stimulated cells) can elicit such an emergency program of gene activation. Among the newly synthesized proteins are cytokines, such as IFN-β and TNF, cell surface receptors with immunological functions, acute phase proteins, and growth factors. This kind of response is not restricted to cells of the immune system but can probably occur in most cell types of the organism. One would expect that there are multiple receptors for pathogens that elicit various intracellular signal transducting systems. These finally reach many different transcription factors in the nucleus which then activate the genes encoding signaling and defense proteins.
Practice : Dentistry
Keywords :