アブストラクト（24巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Reactive Oxygen Species in Apoptosis : Redox Regulation of Programmed Cell Death
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS : Apoptosis
Authors　： Eiichiro Okabe, Kazuo Todoki, Chang-il Lee, Tetsuya Hagiwara, Hirofumi Shoji
Authors（kana）　：
Organization　： Department of Pharmacology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 24
Number　： 2
Page　： 97-106
Year/Month　： 1996 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] Programmed cell death or apoptosis is a process whereby cells die in a controlled manner, in response to specific stimuli, apparently following an intrinsic program. This process provides, for example, a mechanism for deletion of specific cell populations in the developing embryo. Much of our knowledge about the mechanisms underlying apoptosis comes from studies with lymphocytes or immature thymocytes, which readily undergo programmed cell death in response to glucocorticoid hormones. The process is characterized by several early morphological alteration, including plasma membrane blebbing and chromatin condensation. Endogenous endonuclease activation, resulting in the cleavage of host chromatin into oligonucleosome-length DNA fragments, is a characteristic biomedical marker for programmed cell death. Apoptosis requires that the dying cell be metabolically active, and apparently a rise in cytoplasmic Ca2+ concentration appears to serve as a common early signal for the initiation of apoptosis. It is known in LLC-PK1 cells (a renal tubular epithelial cell line) that in response to H2O2 there is an early rise in intracellular free Ca2+ that precedes cell death and that intracellular Ca2+ chelators or antioxidants prevent cell death. Based on this in this short review we considered the mechanisms by which exposure to oxidant stress produces apoptotic cell death.
Practice　： Dentistry
Keywords　： Apoptosis, Reactive oxygen species, Ca2+, Gene signaling, Programmed cell death