アブストラクト（24巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Relevance of Antigen-induced T Cell Death in the Regulation of Immune Responses
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS : Apoptosis
Authors　： Eiro Kubota
Authors（kana）　：
Organization　： Second Department of Oral and Maxillofacial Surgery, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 24
Number　： 2
Page　： 107-110
Year/Month　： 1996 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] Progenitor T cells arise in the bone marrow and are transported to the thymus where they continue to develop. During this period of development, Immature cells of the T cell lineage begin to express cell surface markers such as CD4 and CD8. Prior to these events, the T cell receptor (TCR) undergoes rearrangements resulting in the potential expression of different receptors. Therefore, it is important that the immune system has the ability to eliminate T cells that recognize self-antigens with high affinity (negative selection) and save T cells with reactivity to foreign antigens (positive selection). At the CD4+ CD8+ stage of development, thymocytes encounter antigen-presenting cells (APC) which determine their ultimate fate. These double positive cells may go on and differentiate into a cytotoxic T cell, a helper T cell, or be deleted. One of the remaining questions in thymic development is the paradox of how immature T cells are both positively and negatively selected in a major histocompatibility antigen complex (MHC) restricted manner. Apoptosis of T cells in negative selection is thus important to create the normal T cell repertoire, and disturbance of this selection system may bring about autoimmune disease as well as cancer development. The possible mechanisms of apoptosis and clinical implications of apoptosis dysregulation in T cell development are discussed in this paper.
Practice　： Dentistry
Keywords　： T lymphocytes, Thymus, Negative selection, Positive selection, Apoptosis