アブストラクト（25巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Interaction of Extracellular Matrix with Osteoclast Integrin αvβ3
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS : Adhesion Molecule
Authors　： Nobuyuki Tani-Ishii, Akira Tsunoda, Toshio Teranaka
Authors（kana）　：
Organization　： Department of Operative Dentistry and Endodontics, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 25
Number　： 2
Page　： 93-98
Year/Month　： 1997 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] Osteoclast interaction with extracellular matrix drives the sequential events that end with bone resorption. Osteoclast express β1 and β3 integrins are involved in the attachment to purified bone matrix proteins. The binding of osteopontin and bone sialoprotein is mediated by αvβ3, while a β1 integrin is responsible for attachment to fibronectin, collagen and thrombospondin. The attachment of osteoclasts to bone is also inhibited by soluble osteopontin, Arg-Gly-Asp-containing peptides derived from both osteopontin and bone sialoprotein. Osteoclast adherence to bone and subsequent resorption of its matrix are dependent on interactions between the osteopontin and/or bone sialoprotein and the integrin αvβ3. Osteopontin is a ubiquitous highly phosphorylated glycoprotein and a major component of the mineralized bone extracellular matrix. Osteopontin has also been identified in many cell types and tissues, and it is clear that a multitude of functions can be attributed to this widely distributed protein. Previously, osteopontin mRNA was expressed in osteoclasts with tartrate-resistant acid phosphatase (TRAP) positively within resorption lacuna. The osteoclasts and immediate resorption surfaces also expressed osteopontin. We investigated the role of osteopontin in the osteoclast differentiation and bone resorption by osteopontin antisense in vitro. Osteopontin antisense oligomers significantly decreased both TRAP - positive and multinucleated cells. This short review focused on osteoclast adherence via αvβ3 to bone matrix and the role of osteopontin on osteoclast.
Practice　： Dentistry
Keywords　： Osteoclast, Integrin, Osteopontin, Extracellular matrix