アブストラクト（27巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Interleukin-1 Induces Production of Matrix Metalloproteinases in Rat Temporomandibular Joint Chondrocytes and Disc Cells
Subtitle　： Selective Proceedings of 33rd General Meeting of Kanagawa Odontological Society, 1998
Authors　： Yoshihiro Ijima, Masaru Kobayashi, Kenji Suzuki, Eiro Kubota
Authors（kana）　：
Organization　： Second Department of Oral and Maxillofacial Surgery, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 27
Number　： 1
Page　： 64-66
Year/Month　： 1999 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [ABSTRACT] The aim of this study is to identify cellular sources of matrix metalloproteinases (MMPs) in the temporomandibular joint (TMJ) and to examine the effect of interleukin-1 (IL-1) on their MMP production. Chondrocytes (Ch) and disc cells (DC) were isolated from rat TMJs with arthritis caused by injection of hrIL-1α, and from TMJs injected with normal saline. Conditioned media from the cultures of these cells contained 72/66 kDa and 92/83 kDa proteinases and they were identified as MMP2 and MMP9, respectively. Both types of cells constitutively produced pro- and active-MMP2. Constitutive production of pro-MMP9 was, however, observed only in the DC but not in the Ch. Whereas IL-1 exhibited no remarkable effect on MMP2 production, it induced the production of pro-MMP9 in the Ch and significantly augmented the production and activation of MMP9 in the DC. These data suggest that MMP9 may be predominantly produced by DC stimulated with IL-1 and possibly plays an important role in cartilage destruction in arthritic TMJs.
Practice　： Dentistry
Keywords　： Temporomandibular joint, Matrix metalloproteinase, Chondrocytes, Disc cells, Interleukin-1 alpha