アブストラクト（28巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Inflammatory Pain Mediators Detected in Temporomandibular Disorders : Eicosanoids in the Synovial Fluid
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS : Biochemical Changes Associated with the Pathology of Temporomandibular Disorders
Authors　： KenIchiro Murakami, Isao Yamamura
Authors（kana）　：
Organization　： Department of Oral and Maxillofacial Surgery, Graduate School and Faculty of Medicine, Kyoto University
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 28
Number　： 2
Page　： 121-126
Year/Month　： 2000 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] The aim of this review paper is to summarize current research into the detection of pain and inflammatory mediators in the synovial fluid of patients with temporomandibular disorders (TMD). The role and biological significance of eisosanoids such as PGE2 and LTB4 is described. There have been investigations of eicosanoids in the synovial fluid of human rheumatoid and osteoarthritis since the 1980s, but it was not until 1991 that PGE2 and LTB4 was first identified in TMJ synovial fluid by Quinn and Basan. They reported on a positive correlation between the synovitis index and the concentrations of the two substances, but a subsequent study by Murakami and his colleague did not find a similar correlation. Recently Alstergren and Kopp claimed that they had found a correlation between pain in jaw movement and PGE2 concentration, but this remains controversial. Although data appear to vary depending on differences in sampling of the synovial fluid and analytical method, we believe that eicosanoids may well be related to the pain and inflammation in TMD.
Practice　： Dentistry
Keywords　： Eicosanoid, Synovial fluid, Temporomandibular joint