アブストラクト（28巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Neuroendocrine and Serotonergic Modulation of Temporomandibular Disorders - A brief review -
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS : Biochemical Changes Associated with the Pathology of Temporomandibular Disorders
Authors　： Sigvard Kopp
Authors（kana）　：
Organization　： Department of Clinical Oral Physiology and Clinical Research Institute of Odontology KAROLINSKA INSTITUTET
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 28
Number　： 2
Page　： 133-137
Year/Month　： 2000 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] Orofacial pain frequently originates from pathological conditions in the masticatory muscles or temporomandibular joints (TMJs). The mediators and mechanisms that monitor pain are of interest in order to find new treatment principles. The neuropeptide substance P (SP), calcitonin gene-related peptide (CGRP) and neuropeptide Y (NPY), have all been found at high levels in the synovial fluid of arthritic TMJs in association with spontaneous pain, while serotonin (5-HT) has been found in association with pain upon movement of the TMJ. Very little is known about pain and inflammatory mediators in muscles. However, we know that 5-HT is involved in the development of pain and tenderness of the masseter muscle in patients with fibromyalgia, whereas local myalgia (myofascial pain) seems to be modulated by other as yet unknown mediators. Interaction within the peripheral nervous system (sensory, sympathetic and serotonergic nerves) is probably of great importance for the modulation of pain in the TMJ and orofacial musculature.
Practice　： Dentistry
Keywords　： Arthritis, Inflammation, Masticatory muscles, Myalgia, Neuropeptides, Pain, Serotonin, Synovial fluid, Temporomandibular disorders, Temporomandibular join