アブストラクト（28巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Role of Cytokines and MMPs Detected in Temporomandibular Disorders
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS : Biochemical Changes Associated with the Pathology of Temporomandibular Disorders
Authors　： Eiro Kubota
Authors（kana）　：
Organization　： Second Department of Oral and Maxillofacial Surgery, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 28
Number　： 2
Page　： 139-143
Year/Month　： 2000 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] Much of the newer biochemical and cellular evidence support the concept that TMJ internal derangements are analogous to many of the same disease processes as other synovial joints in the body. Disc derangement is not purely a mechanical problem, but the disease processes can include immunologically mediated conditions. The importance of proinflammatory cytokines has been recently emphasized in TMJ arthropathies because of their strong action of inducing cartilage matrix degrading enzymes, such as matrix metalloproteinases (MMPs). We agree with other researchers in suggesting that interleukin-1 (IL-1), tumor necrosis factor-alpha (TNFα), and IL-6 are detectable in the synovial fluid (SF) of diseased TMJ. We further confirm that these cytokines are involved in the initiation and/or progression of cartilage destruction in temporomandibular disorders (TMD), by activating MMP9, MMP3 as well as MMP2 synthesis by articular chondrocytes or disc cells. From all of these findings, it is considered that cytokines and MMPs could be feasible markers for catabolic changes in the TMJ.
Practice　： Dentistry
Keywords　： Synovial fluid, Cytokine, Matrix metalloproteinase, Osteoarthritis