アブストラクト（29巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Blockade of Heat Stress Preconditioning by MPG
Subtitle　： Selective Proceedings of 35th General Meeting of Kanagawa Odontological Society, 2000
Authors　： Kazu-ichi Yoshida, Hideyuki Sawada, Munetaka Furuya, Akiyoshi Ohsawa
Authors（kana）　：
Organization　： Department of Anesthesiology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 29
Number　： 1
Page　： 39-41
Year/Month　： 2001 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] We investigated the effect of N-2-mercaptoplopionyl glycine (MPG), a diffusible antioxidant, in rabbit model of heat stress (HS) preconditioning. Group I-Control rabbits treated with anesthetic alolle; Group II-rabbits subjected to HS by raising core temperature to 42℃ for 15 min and Group III-given MPG, beginning 30 min prior to HS and continued up to 15 min post HS. Twenty-four hours later, all animals underwent 30 min of the left anterior descending artery occlusion followed by 180 min of reperfusion. Risk area was delineated by Evan's blue and infarct size determined by tetrazolium staining. The risk area revealed no significant difference among all the groups. Infarct size/area risk decreased significantly in the HS hearts. Treatment with MPG of HS rabbits resulted in a significant increase in the infarct size. The results show that prior HS significantly reduced infarct size which was blocked by MPG. Western blot analysis revealed significant synthesis of HSP 70 in HS rabbit hearts and was blocked with MPG. We conclude that oxidant stress is one of the key mediators of HS induced myocardial protection and triggers the expression of HSP 70.
Practice　： Dentistry
Keywords　： ischemia, reperfusion, heat stress, N-2-mercaptopropionyl glycine