アブストラクト（29巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Basic study of early detection of bone structural change associate with radiation therapy
Subtitle　： Selective Proceedings of 35th General Meeting of Kanagawa Odontological Society, 2000
Authors　： Sirou Kiyohara, Takashi Sakurai, Isamu Kashima
Authors（kana）　：
Organization　： Department of Oral and Maxillofacial Radiology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 29
Number　： 1
Page　： 45-47
Year/Month　： 2001 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] The present study was conducted to investigate the benefits of non-invasive diagnostic methods, including morphological processing and star volume analysis, for the detection of early osseous changes associated with high-dose irradiation. Ten male Wistar rats at 15 weeks of age were used as a model of acute radiation injury. The right distal end of the femur at the knee joint was irradiated once at 30 Gy. Radiography was performed before irradiation and 4 times after irradiation at one-week intervals. Characteristics of skeletal structure were extracted from the obtained image information through morphological processing. ROC curves were drawn for visual evaluation. The extracted skeletal structures were quantified by the star volume method. The results of the ROC analysis revealed that molphological filtered images had a higher ability to visually detect osseous changes than did original images. On quantitative evaluation, the QL value, corresponding to bone mineral density, significantly increased at 3weeks after irradiation (paired t-test, p<0.05). At 2 weeks after irradiation, the skeletal volume (Vsk) decreased on the sumset image 2-5, while the marrow space volume (Vsp) increased, showing significant differences from those observed on the non-irradiated side (paired t-test, P<0.05). These results suggest that a combination of morphological processing and star volume analysis is a method of image engineering analysis that can visually and quantitatively detect osseous changes earlier than do conventional X-ray images.
Practice　： Dentistry
Keywords　： Acute radiation injury, Mathematical morphology, Computed radiography, Star volume analysis