アブストラクト（30巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： The Role of Hepatocyte Growth Factor in Odontogenic Developmental Cysts
Subtitle　： ORIGINAL ARTICLES
Authors　： Takayuki Yamamoto, Yoshihisa Watanabe
Authors（kana）　：
Organization　： Department of Oral Pathology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 30
Number　： 1
Page　： 17-25
Year/Month　： 2002 / 3
Article　： Original article
Publisher　： Kanagawa Odontological Society
Abstract　： Hepatocyte growth factor (HGF) is considered one of the mediators of epithelial-mesen chymal interactions during the morphogenesis of human tooth germs and is considered to be involved in the pathogenesis of odontogenic developmental cysts. We investigated the expression of HGF and its receptor c-Met in odontogenic developmental cysts in immunohistochemical studies and by reverse-transcriptase polymerase chain reaction (RT-PCR). Expression of HGF was detected in the cytoplasm of fibroblasts, and c-Met was detected in the cytoplasm, including the cell membranes of odontogenic epithelium. RT-PCR analysis showed the presence of HGF and c-met mRNA. To examine the direct effects of HGF on proliferation of odontogenic epithelial cells, we used a primary culture of odontogenic epithelium. We found that HGF (20 ng/ml) stimulated the proliferation of odontogenic epithelial cells. Our results suggest that HGF promotes the proliferation of odontogenic epithelial cells.
Practice　： Dentistry
Keywords　： Hepatocyte growth factor (HGF), Odontogenic keratocyst, Dentigerous cyst