アブストラクト（30巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Relationship Between Bone Strength Deterioration and Bone Quality Factors in Osteoporosis : A Basic Study of Three-dimensional Imaging Analysis
Subtitle　： Selective Proceedings of 36th General Meeting of Kanagawa Odontological Society, 2001
Authors　： Suguru Wakabayashi, Takashi Sakurai, Isamu Kashima
Authors（kana）　：
Organization　： Department of Oral and Maxillofacial Radiology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 30
Number　： 1
Page　： 49-52
Year/Month　： 2002 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： The objective of the present study was to clarify the bone quality factors that precipitate the deterioration of bone strength in osteoporosis. ICR mice (10 weeks old) were subjected to ovariectomized (OVX) or shamoperated (Sham) and reared with a free ingestion of the normal food for 6 weeks. At the end of the 6th week, 9 mice in each group (18 in total) were slaughtered in order to extract the femoral distal metaphysis for the sample. Peripheral quantitative computed tomography (pQCT) was used to evaluate total bone mineral density (BMD), total bone area, cortical BMD, cortical thickness, and trabecular BMD. Trabecular structure indices (bone volume, trabecular thickness, trabecular number, trabecular separation, node-strut analysis, connectivity density) were evaluated from micro computed tomography (micro-CT) images with 3D trabecular structure measuring softwar (TRI 3D-BON). Compression tests in the same region measured maximum breaking loads for bone strength. Strong correlations were revealed between bone strength and total BMD (r>0.8), and cortical thickness, trabecular BMD, bone volume, trabecular thickness, trabecular number, and trabecular separation (r>0.7 in each). The results of multiple regression analysis indicated that trabecular thickness and trabecular number strongly influenced to the bone strength. These results suggest that bone strength deterioration at femoral distal metaphysis in osteoporosis is due to cortical thinning and deterioration of cancellous bone, specifically the reduction of trabecular thickness and trabecular number, rather than of
Practice　： Dentistry
Keywords　： Bone mineral density, Trabecular structure Bone strength, Bone quality, Osteoporosis