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アブストラクト（30巻1号：The Bulletin of Kanagawa Dental College）
English
| Title ： | Critical contribution of LFA-1 to concanavaline A induced hepatitis |
|---|---|
| Subtitle ： | Selective Proceedings of 36th General Meeting of Kanagawa Odontological Society, 2001 |
| Authors ： | Goichi Matsumoto, Yasushi Ohmi, Daisuke Tone, Junichi Shindo |
| Authors（kana） ： | |
| Organization ： | 1st Department of Oral and Maxillofacial Surgery, Kanagawa Dental College |
| Journal ： | The Bulletin of Kanagawa Dental College |
| Volume ： | 30 |
| Number ： | 1 |
| Page ： | 59-61 |
| Year/Month ： | 2002 / 3 |
| Article ： | Report |
| Publisher ： | Kanagawa Odontological Society |
| Abstract ： | Concanavalin A(Con A)induced hepatitis is an experimental model of T cell dependent autoimmune hepatitis. We examined the role of LFA-1 in Con A-induced hepatic damage using LFA-1-/-mice. Massive hepatic necrosis-like regions were observed in all LFA-1+/+ mice. In contrast, LFA-1-/- mice were resistant to Con A-induced hepatitis and none of LFA-1-/- mice showed hepatic necrosis-like regions. Whereas activated liver T cells remained in the liver in LFA-1+/+ mice, activated T cells were rapidly cleared from the liver of LFA-1-/- mice. Liver T cells from LFA-1-/- mice showed impaired adhesion to murine hepatocytes in vitro. Adoptive transfer of liver T cells from LFA-1+/+ mice, but not from LFA-1-/- mice, sensitized LFA-1-/- mice to Con A-induced hepatitis. These data indicated that LFA-1 mediated cell to cell interaction between hepatocytes and T cells are crucial for Con A-induced massive hepatitis. |
| Practice ： | Dentistry |
| Keywords ： | Con A induced hepatitis, LFA-1 |
