アブストラクト（30巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Mycoplasma as a causal factor of Temporomandibular Disorder (TMD)
Subtitle　： Selective Proceedings of 36th General Meeting of Kanagawa Odontological Society, 2001
Authors　： Masako Suga, Nobushiro Hamada*, Yoshiaki Kawai, Masaru Kobayashi, Satoshi Shimizu, Toshio Umemoto*, Eiro Kubota
Authors（kana）　：
Organization　： Second Department of Oral and Maxillofacial Surgery, Oral Microbiology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 30
Number　： 1
Page　： 65-66
Year/Month　： 2002 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： The objective of this study is to elucidate possible relationships of Mycoplasma-induced reactive arthritis (ReA) and temporomandibular disorders (TMD). The presence of Mycoplasma fermentans (M.fermentans) in synovial fluid (SF) of the temporomandibular joint (TMJ) was first examined by PCR assay in TMD patients. Two SF samples out of 14 were positive for Mycoplasma DNA. M.fermentans and its cell lysate were further examined whether they could induce cytokine production in murine peritoneal macrophages (PEC). Both whole cell lysate and TritonX-114 extract from M.fermentans could induce TNF-α and IL-1β production from PEC. The cytokine levels were high enough as PEC were stimulated with bacterial lipopolysaccharide (LPS). These results suggest the possible role of M.fermentans as a causal factor of ReA, which further proceeds to TMD.
Practice　： Dentistry
Keywords　： temporomandibulart disorders (TMD), Mycoplasma fermentans, peritoneal macrophases, TNF-α, IL-1β