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アブストラクト(30巻1号:The Bulletin of Kanagawa Dental College)
English
Title : | Involvement of nitric oxide in compression-induced reactive hyperemia of the canine mandibular gingiva |
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Subtitle : | Selective Proceedings of 36th General Meeting of Kanagawa Odontological Society, 2001 |
Authors : | Yoichi Omori, Hiroyuki Miyazaki, Masaichi-Chang-il Lee, Shun-suke Takahashi, Kazuo Todoki |
Authors(kana) : | |
Organization : | Department of Pharmacology, Kanagawa Dental College |
Journal : | The Bulletin of Kanagawa Dental College |
Volume : | 30 |
Number : | 1 |
Page : | 70-72 |
Year/Month : | 2002 / 3 |
Article : | Report |
Publisher : | Kanagawa Odontological Society |
Abstract : | We have examined a possible involvement of nitric oxide (NO・) in reactive hyperemia of the canine mandibular gingiva induced by tissue compression. Blood flow and tissue PO2 of the gingiva, and the systemic hemodynamics were continuously monitored during compression-induced hyperemia. A transient compression of the mandibular gingiva resulted in an immediate decrease in the tissue blood flow and PO2. Upon releasing the pressure, an increase in the blood flow and a recovery of the tissue PO2 were observed. The magnitudes of these responses increased as the duration of tissue compression was prolonged, and were significantly suppressed by application of L-NAME (60 mg/kg, i.a.). The inhibitory effect of L-NAME was partially reversed by L-arginine (60 mg/kg, i.a.). An increase of NO・ concentration was detected during reactive hyperemia in one experiment. These results have suggested a possibility that NO・ is involved in reactive vasodilation that underlies the compression-induced hyperemia of the gingiva, and plays a major role in the maintenance of homeostasis in the gingival circulation. |
Practice : | Dentistry |
Keywords : | Reactive hyperemia, Nitric oxide, Gingiva, Laser Doppler flowmetry, Electrochemistry |