アブストラクト（30巻1号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Modulation of electrophysiological property of colonic AH/type2 neuron by intracellular Ca2+
Subtitle　： Selective Proceedings of 36th General Meeting of Kanagawa Odontological Society, 2001
Authors　： Yutaka Kobayashi, Satoko Wada-Takahashi, Kenji Tamura
Authors（kana）　：
Organization　： Department of Oral Physiology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 30
Number　： 1
Page　： 76-78
Year/Month　： 2002 / 3
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： The role of ryanodine-sensitive Ca2+ channels of the intracellular store sites in modulation of electrical activities of myenteric AH/type 2 neurons was investigated. Membrane hyperpolarization induced by application of caffeine (0.1-10 mM, n=10) suggested that the presence of ryanodine-sensitive Ca2+ channels at the intracellular store sites and opening of Ce2+ -dependent K+ channels in the plasma membrane. The similarity of the spontaneous occurring hyperpolarization to action potential induced after hyperpolarization(AH) and its susceptibility to ryanodine indicated that AH is produced not only by an influx of Ca2+ during the action potential but also by Ca2+ released from the endoplasmic reticulum(ER) through Ca2+ -sensitive Ca2+ channels. Suppression of the caffeine-induced hyperpolarizing action by ryanodine suggested that ryanodine depleted Ca2+ from intracellular store sites through the ryanodine-sensitive Ca2+ channels. These results indicated that regulation of cytoplasmic free Ca2+ concentration through the intracellular Ca2+ storage system plays an important role in the control of membrane excitability of myenteric AH/type 2 neuron and to maintain its membrane potential at rest.
Practice　： Dentistry
Keywords　： Ca2+, AH/type2 neuron, Colon, Guinea pig, Ryanodine